University of Iowa, Iowa City, Iowa 52246
: Ph.D. Pharmaceutics


PROFESSIONAL EXPERIENCE

University of Iowa, College of Pharmacy

2008 – Present: Research Scientist, University of Iowa Pharmaceuticals Development Consortium
2008 – Present: Assistant Editor, AAPS PharmSciTech journal
2007 – 2008: Research Scientist, Center for Advanced Drug Development
• Conducted analytical method development and validation, as well as pre-formulation studies for a variety of dosages forms.
• Wrote and reviewed protocols and reports for contract projects.

IVAX Research Inc. Miami, Florida

2003 – 2006: Director, Department of Analytical Research and Development

• Managed analytical research and development for Injection, solid and semisolid dosages forms.
• Managed a stability study group handling stability studies for a variety of dosage forms.
• Wrote or reviewed annual reports for stability studies of IND and ANDA submission batches, exhibit batches and annual check batches.
• Reviewed validation protocols, validation reports for capsules, tablets, injections and swab testing.
• Supervised QC testing.
• Conducted compatibility studies for injection and involved in the trouble shooting of products.
• Supervised preventive maintenance, calibration, upgrade and new purchase of instruments, as well as the software maintenance and upgrade.




University of Iowa, College of Pharmacy, Pharmaceutical Services

1997 – 2003: Research Scientist, Quality Control Manager
1997: Interim Quality Control Manager
• Managed QC unit with a laboratory manager and an analytical R & D unit with a supervisor.
• Supervised analytical R & D on method development and validation for chemical, chiral, ion exchange and size exclusion HPLC analyses of small molecular drugs, peptides, proteins, carbohydrates and lipids.
• Supervised method transfers.
• Supervised pre-formulation studies: TGA, DSC, hot stage microscopy, powder X ray diffraction, pKa determination and Karl Fischer titration for drug substances.
• Worked with Pharmaceutical Service director or other project leaders to provide cost estimate and approaches to accomplish tasks.
• Communicated with clients in responding to their requests.
• Reviewed batch records.
• Supervised HPLC upgrades to be 21 CFR Part 11 compliant.

1996 – 1997: Associate Research Scientist, Analytical Research and Development
1992 – 1996: Assistant Research Scientist, Analytical Research and Development
1990 – 1992: Visiting Professor
• Conducted contract projects on product development and stability studies for NCI (National Cancer Institute) and pharmaceutical companies.
• Conducted method development and validation for different new drugs.

National Defense Medical Center, Taiwan

1988 – 1990: Head and Senior Research Scientist, Section of Pharmacy, Institute of Preventive Medicine.
1983 –1988: Deputy Head and Research Scientist, Section of Pharmacy, Institute of Preventive medicine.
1982 –1983: Research Scientist, Section of Pharmacy, Institute of Preventive Medicine.
1982 –1990: Associate Professor of Pharmaceutics, School of Pharmacy.
• Conducted separation, purification and identification of antibiotics from fermentation broth.
• Provided burn dressing for clinical trials on burn patients.
• Lectured on part of the two courses: Physical Pharmacy, and Biopharmaceutics and Pharmacokinetics.

University of Iowa, College of Pharmacy

1978 – 1982: Teaching Assistant and Research Assistant, College of Pharmacy, the University of Iowa.


ORGANIZATIONS

The America Association of Pharmaceutical Scientists (AAPS)


SCIENTIFIC PUBLICATIONS

1. Ronald D. Schoenwald and Hong-Shian Huang, “Corneal Penetration Behavior of beta-Blocking Agents. I: Physical-Chemical Factors,” J. Pharm. Sci., 72, 1266 (1983).

2. H. S. Huang, R. D. Schoenwald, and J. L. Lach, “Corneal Penetration Behavior of beta-Blocking Agents. II. Assessment of Barrier Contributions,” J. Pharm. Sci., 72, 1272 (1983).

3. H. S. Huang, R. D. Schoenwald, and J. L. Lach, “Corneal Penetration Behavior of beta-Blocking Agents. III. In Vitro- In Vivo Correlations,” J. Pharm. Sci., 72, 1279 (1983).

4. C. H. Chiang, H. S. Huang, and R. D. Schoenwald, “Corneal Permeability of Adrenergic Agents Potentially Useful in Treating Glaucoma,” Journal of the Taiwan Pharmaceutical Association, 38, 67 (1987)

5. C. H. Chiang, C. Y. Wu, and H. S. Huang, “Hydrolysis Kinetics of Diacetyl Nadolol,” J. Pharm. Sci., 76, 914 (1987).

6. H. S. Huang, “Correlation of Pharmaceutics between Men and Animals,” Journal of Hospital Pharmacy (of Taiwan), 4(1), 106 (1987).

7. K. D. Kao, D. W. Lu, C. H. Chiang, and H. S. Huang, “Corneal and Scleral Penetration Studies of 6-Hydroxy-ethoxy-2-benzothiazolw Sulfonamide: A topical Carbonic Anhydrase Inhibitor.” Journal of Ocular Pharmacology 6(4), 313, 1990.

8. C. Y. Wu, C. H. Chiang, and H. S. Huang, In-Vitro Corneal Permeability of Cephalosporins, The Chinese Pharmaceutical Journal 43(3), 1991.

9. H. S. Huang, J. R. Wu, and M. L. Chen, “Reversed-Phase High Performance Liquid Chromatography of beta-Lactams –Effect of Columns, Ion-Pairing Reagents, and Mobile Phase pHs on their Retentions,” Journal of Chromatography, 564, 195, 1991.

10. Ramakrishna R. Gadiraju, Rolland Poust, and Hong-Shian Huang, The effect of Buffer Species, pH and Buffer Strength on the Critical Micelle Concentration and Solubility of Amiodarone HCl, The Tenth Annual Meeting of American Association of Pharmaceutical Scientists, November 5-9, 1995, Miami Beach, Florida.

11. Zhixin Zong, Salil Desai, Hong-Shian Huang, Aditya Kaushal, Dewey H. Barich, Raj Suryanarayanan, Eric J. Munson, and Lee Kirsch, The Stabilizing Effect of Moisture on the Solid-State Degradation of Gabapentin, The 2009 Annual Meeting of American Association of Pharmaceutical Scientists, November 7-12, 2009, Los Angeles, California.


UNPUBLISHED RESEARCH REPORTS

1. H. S. Huang and J. L. Lach, “Compatibility Study of Levothyroxine with Tablet Excipients using Diffuse Reflectance Spectroscopy,” 1979.

2. J. L. Lach and H. S. Huang, “Dissolution of Diltiazem HCl Tablets in Simulated Gastric Fluid: Effect of Formulation and Processing Factors,” January 1982.

3. H. S. Huang and T. R. Chang, “Separation and Purification of Griseorhodin Antibiotics by Cellulose Column,” September 1985.

4. H. S. Huang and T. R. Chang, “Determination of Protein Binding Constant for Griseorhodin A,” September 1985.

5. H. S. Huang and T. R. Chang, “Simultaneous Analysis of Griseorhodin Antibiotics by Reversed Phase HPLC,” September 1985.

6. H. S. Huang and J. R. Wu, “Normal Phase HPLC Analysis of Kinamycin D and its Analogues,” September 1989.

7. H. S. Huang and H. Y. Lee, “Ion-Pair HPLC for Simultaneous Analysis of Eight Known Aminoglycosides, and its Application to the Screening of New Amino-Glycosides from Extracts of Fermentation Broth,” December 1989.

8. H. S. Huang, F. J. Kao, and H. Y. Lee, “Control of Experimental Burn Wound Infections on Mice: Sustained Release of Silver Sulfadiazine from Spray Dressing Containing Polymers,” March 1990.



INVITED SYMPOSIA

1. “Factors Involved in Corneal Absorption of Anti-Glaucoma Drugs.” The 16th Symposium on Military Medicine, National Defense Medical Center, Taipei, Taiwan, November 1982.

2. “Structure-Activity Relationship of beta-Blockers to be Used in Eye Drops for Glaucoma,” Seminar Series, Department of Pharmacology, National Defense Medical Center, Taipei, Taiwan, November 1985.

3. “Burn Dressings – Preparations and Clinical Applications,” Veterans Pharmaceutical Plant, Product Development Seminar Series, Chong-Li, Tao-Yuan, Taiwan, October 1988.

4. “Physico-Chemical Properties of Three Types of Burn Dressings: I. Poly-Hydroxyethylmethacrylate Film Dressing, II. Collagen/Silicon Composite Dressings, III. Spray Dressing with Antimicrobial Agents,” Department of Surgery, Air Force General Hospital, Taipei, Taiwan, October 1988.

5. “The Preparations and Clinical Evaluation of Poly-Hydroxyethylmethacrylate Film Dressings and Spray Dressings,” College of Pharmacy, University of Iowa, Iowa City, Iowa, September 1990.

6. “The Formulation and Stability Study of Peptide Drugs,” Veterans Pharmaceutical Plant, Product Development Seminar Series, Chong-Li, Tao-Yuan, May 1993.

7. “The Physico-Chemical Properties of Peptides,” Seminar Series, School of Pharmacy, National Defense Medical Center, Taipei, Taiwan, May 1993.

8. “The Use of Instruments for the R & D of Lyophilization,” School of Pharmacy, National Defense Medical Center, Taipei, Taiwan, September 26, 2009.